منابع مشابه
Redundancy in Genotyping Arrays
Despite their unprecedented density, current SNP genotyping arrays contain large amounts of redundancy, with up to 40 oligonucleotide features used to query each SNP. By using publicly available reference genotype data from the International HapMap, we show that 93.6% sensitivity at <5% false positive rate can be obtained with only four probes per SNP, compared with 98.3% with the full data set...
متن کاملComputational Arrays with Flexible Redundancy
AbstmctDifferent multiple redundancy schemes for fault detection and correction in computational arrays are proposed and analyzed. The basic idea is to embed a logical array of nodes onto a processor/switch array such that d processors, 1 2 d 5 4, are dedicated to the computation associated with each node. The input to a node is directed to the d processors constituting that node, and the outpu...
متن کاملDistributing Orthogonal Redundancy on Adaptive Disk Arrays
When upgrading storage systems, the key is migrating data from old storage subsystems to the new ones for achieving a data layout able to deliver high performance I/O, increased capacity and strong data availability while preserving the effectiveness of its location method. However, achieving such data layout is not trivial when handling a redundancy scheme because the migration algorithm must ...
متن کاملGenotyping and annotation of Affymetrix SNP arrays
In this paper we develop a new method for genotyping Affymetrix single nucleotide polymorphism (SNP) array. The method is based on (i) using multiple arrays at the same time to determine the genotypes and (ii) a model that relates intensities of individual SNPs to each other. The latter point allows us to annotate SNPs that have poor performance, either because of poor experimental conditions o...
متن کاملDevelopment of SNP-genotyping arrays in two shellfish species.
Use of SNPs has been favoured due to their abundance in plant and animal genomes, accompanied by the falling cost and rising throughput capacity for detection and genotyping. Here, we present in vitro (obtained from targeted sequencing) and in silico discovery of SNPs, and the design of medium-throughput genotyping arrays for two oyster species, the Pacific oyster, Crassostrea gigas, and Europe...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2007
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000287